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Randomized Controlled Trial
. 2010 May;196(5):372-6.
doi: 10.1192/bjp.bp.109.066050.

Effect of early intervention on 5-year outcome in non-affective psychosis

Rafael Gafoor  1 , Dorothea Nitsch, Paul McCrone, Tom K J Craig, Philippa A Garety, Paddy Power, Philip McGuire
Affiliations
Randomized Controlled Trial

Effect of early intervention on 5-year outcome in non-affective psychosis

Rafael Gafoor et al. Br J Psychiatry. 2010 May.

Abstract

Background: Early specialised care may improve short-term outcome in first-episode non-affective psychosis, but it is unclear if these benefits endure.

Aims: To assess the long-term effect of early intervention in psychosis.

Method: Individuals with first-episode psychosis were randomised to specialised care or care as usual (trial number: ISRCTN73679874). Outcome after 5 years was assessed by case-note review.

Results: There were no significant differences in the admission rate (coefficient 0.096, 95% CI -0.550 to 0.742, P = 0.770) or the mean number of bed days (coefficient 6.344, 95% CI -46 to 58.7, P = 0.810).

Conclusions: These findings that specialist intervention did not markedly improved outcome at 5 years accord with those from a larger OPUS study. The sample size of this study was small and these results should be generalised with caution. More research is needed.

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