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Review
. 2010 May:85:27-39.
doi: 10.3899/jrheum.091463.

Tumor necrosis factor and anti-tumor necrosis factor therapies

Edward C Keystone  1 , Carl F Ware
Affiliations
Review

Tumor necrosis factor and anti-tumor necrosis factor therapies

Edward C Keystone et al. J Rheumatol Suppl. 2010 May.

Abstract

Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-based therapies.

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