Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jul;19(3):101-6.
doi: 10.4103/0971-4065.57106.

Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress

K R Shanmugam  1 , C H Ramakrishna, K Mallikarjuna, K Sathyavelu Reddy
Affiliations

Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress

K R Shanmugam et al. Indian J Nephrol. 2009 Jul.

Abstract

Diabetes is a major threat to global public health, and the number of diabetic patients is rapidly increasing worldwide. Evidence suggests that oxidative stress is involved in the pathophysiology of diabetic complications and alcoholic diseases. The aim of this study is to find out the impact of alcohol on lipid metabolic profiles in kidney tissue under streptozotocin induced diabetic condition. No study has been reported so far on the effect of alcohol on diabetic condition and also with reference to lipid metabolic profiles. Hence, the present study has been designed to elucidate the impact of alcoholism on diabetic condition. Male wistar strain albino rats were randomly divided into four groups: control (saline treated) NC, alcohol-treated (At), diabetic control (DC), and alcohol-treated diabetic rats (D+At). In alcohol-treated diabetic rats, we observed high levels of MDA, total cholesterol, triglycerides, phospholipids and also high levels of blood glucose than other groups. Moreover, degenerative changes of renal cells in alcohol-treated diabetic group were maximized by administration of alcohol as evinced by histopathological examination. This study suggests that alcohol consumption could be an aggravation factor which contributes for the formation of free radicals in diabetic condition. Therefore, consumption of alcohol during diabetic condition is harmful.

Keywords: Alcohol; diabetes; lipid metabolic profiles; rats.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) Photo micro graph of normal control kidney renal parenchyma showing normal architecture with normal Bomens capsule. (b) Photo micro graph of alcohol-treated (At) kidney showing 1. Severe necrosis of the cells 2. Severe congestion of blood vessels. (c) Photo micro graph of diabetic control kidney showing 1. Severe tubular degeneration, 2. Focal necrosis of tubules. (d) Photo micro graph of diabetic + alcohol treated (D+At) rat kidney showing 1. Hyaline casts, 2. Dilatation of Bowmens capsule, 3. Tubular damage.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Pari L, Latha M. Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. Singapore Med J. 2002;43:617–21. - PubMed
    1. Palanduz S, Ademoglu E, Gokkusu C, Tamer S. Plasma antioxidants and type 2 diabetes mellitus. Res Commun Mol Pathol Pharmacol. 2001;109:309–18. - PubMed
    1. Warso MA, Lands WE. Lipid peroxidation in relation to prostacyclin and thromboxane physiology and pathophysiology. Br Med Bull. 1983;39:277–80. - PubMed
    1. Jaiprakash R, Naga Rani MA, Venkataraman BV. Effect of felodipine on serum lipid profile in short term streptozotocin diabetes in rats. Indian J Exp Biol. 1993;31:283–4. - PubMed
    1. Singh BM, Palma MA, Nattrass M. Multiple aspects of insulin resistance. Comparison of glucose and intermediary metabolite response to incremental insulin infusion in IDDM subjects of short and long duration. Diabetes. 1987;36:740–8. - PubMed