Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Jul;19(3):115-8.
doi: 10.4103/0971-4065.57109.

Calciphylaxis in chronic renal failure: An approach to risk factors

W Rezaie  1 , H A J M Overtoom, M Flens, R J L Klaassen
Affiliations
Case Reports

Calciphylaxis in chronic renal failure: An approach to risk factors

W Rezaie et al. Indian J Nephrol. 2009 Jul.

Abstract

We present a case of calcifying panniculitis due to calciphylaxis in a nontherapy compliance 65-year-old man suffering from chronic renal failure. Calciphylaxis, a life threatening condition, is characterized by high calcium x phosphate product, presence of calcium crystals in the skin and secondary hyperparathyroidism. The clinical presentation includes painful firm plaques, which could progress to nonhealing ulcers. A review of literature is given with emphasis on identification of risk factors and early diagnosis.

Keywords: Calciphylaxis; chronic renal failure; panniculitis; secondary hyperparathyroidism.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Multiple painful indurated plaques on both lower extremities
Figure 2a
Figure 2a
Soft tissue x-ray showed increased density on medial aspect of right lower leg
Figure 2b
Figure 2b
CT images of lower extremities showed calcified vessels and subcutaneous calcification
Figure 3a
Figure 3a
H and E stain of skin lesions showed lobular dystrophic calcified panniculitis and adipose tissue necrosis
Figure 3b
Figure 3b
A von Kossa stain of the same case demonstrates calcium deposits in subcutaneous fat and in the walls of vessels
See this image and copyright information in PMC

References

    1. Janigan DT, Hirsch DJ, Klassen GA, MacDonald AS. Calcified subcutaneous arterioles with infarcts of the subcutis and skin (Calciphylaxis) in chronic renal failure. Am J kidney dis. 2000;35(4):588–97. - PubMed
    1. Essary LR, Wick MR. Cutaneous calciphylaxis: an underrecognized clinicopathoogic entity. Am J Clin Pathol. 2000;113:280–7. - PubMed
    1. Requena L, Sanchez Yus E. Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol. 2001;45:325–61. - PubMed
    1. Fine A, Zacharias J. Calciphylaxis is usually non-ulcerating: Risk factors, outcome and therapy. Kidney Int. 2002;61:2210–17. - PubMed
    1. Ivker RA, Woosley J, Briggaman RA. Calciphylaxis in three patients with end-stage renal disease. Arch dermatol. 1995;131(1):63–8. - PubMed

Publication types