The use of isotretinoin in acne
- PMID: 20436884
- PMCID: PMC2835909
- DOI: 10.4161/derm.1.3.9364
The use of isotretinoin in acne
Abstract
Systemic isotretinoin remains the most efficacious treatment for severe acne as well as many cases of more moderate disease that are unresponsive to other treatment modalities. The current chapter outlines the mechanisms behind the excellent efficacy, describes how to optimize treatment, reviews the recommended guidelines for monitoring and summarizes adverse effects.
Keywords: European Directive; acne; isotretinoin; relapse; teratogencity.
References
-
- Fogh K, Voorhees JJ, Astrom A. Expression, purification and binding properties of human cellular retinoic acid-binding protein type I and II. Arch Biochem Biophys. 1993;300:751–755. - PubMed
-
- Levin AA, Bosakowski T, Kazmer S, Grippo JF. 13-cis retinoic acid does not bind to retinoic acid receptors alpha, beta and gamma. Toxicologist. 1992;12:181.
-
- Ott F, Bollag W, Geiger JM. Oral 9-cis-retinoic acid in acne therapy. Dermatology. 1996;193:124–126. - PubMed
-
- Geiger JM, Hommel L, Harms M, Saurat JH. Oral 13-cis-retinoic acid is superior to 9-cis-retinoic acid in sebosuppression in human beings. J Am Acad Dermatol. 1996;34:513–515. - PubMed
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