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. 2010 Apr 30;25(6):763-6.
doi: 10.1002/mds.22839.

The changing face of Parkinson's disease-associated psychosis: a cross-sectional study based on the new NINDS-NIMH criteria

Gilles Fénelon  1 , Thierry Soulas, Franck Zenasni, Laurent Cleret de Langavant
Affiliations

The changing face of Parkinson's disease-associated psychosis: a cross-sectional study based on the new NINDS-NIMH criteria

Gilles Fénelon et al. Mov Disord. .

Abstract

New criteria for Parkinson's disease-associated psychosis (PDAP) were recently proposed by a NINDS-NIMH working group. We assessed 116 consecutive unselected outpatients with PD for the existence of psychotic symptoms during the previous month, using a structured questionnaire covering the whole spectrum of PDAP symptoms. Hallucinations occurred in 42% of the patients (visual: 16%; nonvisual: 35%), delusions in 4%, and minor symptoms in 45% (sense of presence, visual illusions, or passage hallucinations). The prevalence of PDAP was 43% when the usual definition was used (hallucinations and/or delusions) and 60% when the NINDS-NIHM criteria were used. Correlations between PDAP and patient characteristics varied with the definition of PDAP. These findings suggest that the epidemiology of PDAP should be re-evaluated with the new criteria. Minor symptoms and nonvisual hallucinations are an important part of the PDAP spectrum, which has commonly been restricted to visual hallucinations and delusions.

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Figures

FIG. 1
FIG. 1. Distribution of psychotic symptoms in 116 consecutive PD outpatients
Psychotic symptoms include hallucinations and delusions (white bars) and minor phenomena (grey bars). The proportion of patients with psychosis (black bars) is shown, based on the usual definitions (hallucinations or delusions) and the new NINDS-NIMH criteria (hallucinations, delusions, sense of presence, or visual illusions). Values are percentages.
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