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. 2010 May 26;132(20):6900-1.
doi: 10.1021/ja101939r.

A new entry of amination reagents for heteroaromatic C-H bonds: copper-catalyzed direct amination of azoles with chloroamines at room temperature

Tsuyoshi Kawano  1 , Koji Hirano, Tetsuya Satoh, Masahiro Miura
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A new entry of amination reagents for heteroaromatic C-H bonds: copper-catalyzed direct amination of azoles with chloroamines at room temperature

Tsuyoshi Kawano et al. J Am Chem Soc. .

Abstract

Chloroamine serves as an efficient amination reagent to the heteroaromatic C-H bond of azole under copper catalysis even at room temperature. This catalysis enables a rapid and concise construction of aminoazoles of great interest in biological and medicinal chemistry.

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