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. 2010 May;82(5):838-45.
doi: 10.4269/ajtmh.2010.08-0383.

Congenital Trypanosoma cruzi infection. Efficacy of its monitoring in an urban reference health center in a non-endemic area of Argentina

Ana María De Rissio  1 , Adelina Rosa Riarte, Miriam Martín García, Mónica Inés Esteva, Marta Quaglino, Andrés Mariano Ruiz
Affiliations

Congenital Trypanosoma cruzi infection. Efficacy of its monitoring in an urban reference health center in a non-endemic area of Argentina

Ana María De Rissio et al. Am J Trop Med Hyg. 2010 May.

Erratum in

  • Am J Trop Med Hyg. 2010 Jun;82(6):1202

Abstract

Congenital transmission (CT) has acquired relevance in Chagas disease (CHD). A cohort of pregnant CHD women (4,355) and their babies were studied in the period 1994-2004. Children were excluded when they had received blood transfusions, or were born or had been in endemic areas; CT rate was 6.1%. Babies were diagnosed between months 1 and 5 in 68.9% of the cases and between months 6 and 12 in 31.1%. In the latter group, parasitemia was detected in 94% and serology in 74.7%. Between months 6 and 9, parasitemia diagnosed 36.2% (P = 0.000) more cases than serology. If serology had been the diagnosis method, those children would have been considered CT free. Taking the overall outcomes, 38.1% of babies were CT free, and 55.8% did not complete the follow-up. Establishing CT as a public health priority and improving first-line health service, congenital CHD coverage could be more efficient in endemic countries.

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Figures

Figure 1.
Figure 1.
formula image Total number of mothers referred per year. ■ Chagas disease mothers per year. –▲– Rate of serological prevalence. The serological prevalence was 49.5 ± 5.1% (mean ± SD) in the sub-period 1997–2004.
Figure 2.
Figure 2.
Twenty-seven percent of Chagas disease mothers were from Bolivia, a neighboring country; 26% of mothers were from the main urban areas of Argentina, City of Buenos Aires and Greater Buenos Aires. The rest were from the different endemic Argentinian provinces.
Figure 3.
Figure 3.
formula image Number of Chagas disease mothers. ■ Children with congenital Trypanosoma cruzi infection. –▲–Rate of congenital transmission. Overall congenital transmission was 6.1 ± 1.1% (mean ± SD).
Figure 4.
Figure 4.
The 68.9% of babies were diagnosed with congenital Trypanosoma cruzi infection since the perinatal period up to the 5th month of life. The rest, 31.1%, were diagnosed during the second semester of life.
Figure 5.
Figure 5.
Outcome of 4,355 children born to Chagas disease mothers along the follow-up. Congenital transmission: positive diagnosis at any point of the first 12 months of life. No congenital transmission: confirmed as non-infected at the end of the follow-up, i.e., 12 months of age. Discontinuous control: two negative controls before the 10th month and absence of a third control.
See this image and copyright information in PMC

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