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Review
. 2010 Jun;7(6):340-7.
doi: 10.1038/nrclinonc.2010.61. Epub 2010 May 4.

Gene-expression-based prognostic assays for breast cancer

Chungyeul Kim  1 , Soonmyung Paik
Affiliations
Review

Gene-expression-based prognostic assays for breast cancer

Chungyeul Kim et al. Nat Rev Clin Oncol. 2010 Jun.

Abstract

Several gene-expression-based reference laboratory tests are now available for prognostication of patients diagnosed with breast cancer. For clinical oncologists, it is important to understand the clinical contexts for which these assays were developed in order to use them properly. This Review is aimed at providing a conceptual and technical overview of the steps involved in the development of gene-expression profiling-based prognostic assays. MammaPrint and Oncotype DX, two widely utilized assays, are compared with respect to differences in the clinical contexts for their development, technologies used, and clinical utilities with the aim of providing a guide to clinical oncologists for utilization of these assays.

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References

    1. BMC Genomics. 2006 Oct 30;7:278 - PubMed
    1. N Engl J Med. 2004 Dec 30;351(27):2817-26 - PubMed
    1. J Clin Oncol. 2008 Feb 10;26(5):729-35 - PubMed
    1. J Clin Oncol. 2006 Aug 10;24(23):3726-34 - PubMed
    1. Nature. 2000 Aug 17;406(6797):747-52 - PubMed