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. 2010 Aug;41(1):14-22.
doi: 10.1007/s11262-010-0487-2. Epub 2010 May 4.

An avian influenza A(H11N1) virus from a wild aquatic bird revealing a unique Eurasian-American genetic reassortment

Shailesh Pawar  1 , Alok Chakrabarti, Sarah Cherian, Satish Pande, Madhuri Nanaware, Satish Raut, Biswajoy Pal, Santosh Jadhav, Sadhana Kode, Santosh Koratkar, Vishal Thite, Akhilesh Mishra
Affiliations

An avian influenza A(H11N1) virus from a wild aquatic bird revealing a unique Eurasian-American genetic reassortment

Shailesh Pawar et al. Virus Genes. 2010 Aug.

Abstract

Influenza surveillance in different wild bird populations is critical for understanding the persistence, transmission and evolution of these viruses. Avian influenza (AI) surveillance was undertaken in wild migratory and resident birds during the period 2007-2008, in view of the outbreaks of highly pathogenic AI (HPAI) H5N1 in poultry in India since 2006. In this study, we present the whole genome sequence data along with the genetic and virological characterization of an Influenza A(H11N1) virus isolated from wild aquatic bird for the first time from India. The virus was low pathogenicity and phylogenetic analysis revealed that it was distinct from reported H11N1 viruses. The hemagglutinin (HA) gene showed maximum similarity with A/semipalmatedsandpiper/Delaware/2109/2000 (H11N6) and A/shorebird/Delaware/236/2003(H11N9) while the neuraminidase (NA) gene showed maximum similarity with A/duck/Mongolia/540/2001(H1N1). The virus thus possessed an HA gene of the American lineage. The NA and other six genes were of the Eurasian lineage and showed closer relatedness to non-H11 viruses. Such a genetic reassortment is unique and interesting, though the pathways leading to its emergence and its future persistence in the avian reservoir is yet to be fully established.

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Figures

Fig. 1
Fig. 1
Phylogenetic trees constructed by the neighbour joining method as implemented in MEGA. Scale bar indicates the number of nucleotide substitutions per site. Highlighted in magenta is the Indian H11N1 isolate, the other H11N1 isolates are shown in red, while other H11 subtypes are in blue. The top BLAST hits for the neuraminidase and matrix genes are shown in green. a Hemagglutinin gene, b neuraminidase gene, c matrix gene
Fig. 1
Fig. 1
Phylogenetic trees constructed by the neighbour joining method as implemented in MEGA. Scale bar indicates the number of nucleotide substitutions per site. Highlighted in magenta is the Indian H11N1 isolate, the other H11N1 isolates are shown in red, while other H11 subtypes are in blue. The top BLAST hits for the neuraminidase and matrix genes are shown in green. a Hemagglutinin gene, b neuraminidase gene, c matrix gene
Fig. 1
Fig. 1
Phylogenetic trees constructed by the neighbour joining method as implemented in MEGA. Scale bar indicates the number of nucleotide substitutions per site. Highlighted in magenta is the Indian H11N1 isolate, the other H11N1 isolates are shown in red, while other H11 subtypes are in blue. The top BLAST hits for the neuraminidase and matrix genes are shown in green. a Hemagglutinin gene, b neuraminidase gene, c matrix gene
See this image and copyright information in PMC

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