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. 2010 Jun 4;12(11):2594-7.
doi: 10.1021/ol100803e.

Direct synthesis of trisubstituted isoxazoles through gold-catalyzed domino reaction of alkynyl oxime ethers

Masafumi Ueda  1 , Aoi Sato, Yuki Ikeda, Tetsuya Miyoshi, Takeaki Naito, Okiko Miyata
Affiliations

Direct synthesis of trisubstituted isoxazoles through gold-catalyzed domino reaction of alkynyl oxime ethers

Masafumi Ueda et al. Org Lett. .

Abstract

Alkynyl oxime ether underwent a gold-catalyzed domino reaction involving cyclization and subsequent Claisen-type rearrangement to afford trisubstituted isoxazoles in a direct, efficient, and regioselective manner. The products were successfully applied to the synthesis of unusual heterocycles as an illustration of the potential utility of the reaction.

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