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Comparative Study
. 2010 Jun 15;201(12):1909-18.
doi: 10.1086/652748.

Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola

Paul Roddy  1 , Sara L Thomas, Benjamin Jeffs, Pascoal Nascimento Folo, Pedro Pablo Palma, Bengi Moco Henrique, Luis Villa, Fernando Paixao Damiao Machado, Oscar Bernal, Steven M Jones, James E Strong, Heinz Feldmann, Matthias Borchert
Affiliations
Comparative Study

Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola

Paul Roddy et al. J Infect Dis. .

Abstract

Background: Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)-recommended case definitions for MHF.

Methods: Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity.

Results: A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our data-derived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions.

Conclusions: Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.

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Conflict of interest statement

Potential conflicts of interest: none reported.

Figures

Figure 1
Figure 1
Uige Provincial Hospital’s Marburg ward receiving a triaged patient with Marburg hemorrhagic fever–compatible symptoms.
See this image and copyright information in PMC

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