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Comment
. 2010 May 5;29(9):1473-4.
doi: 10.1038/emboj.2010.67.

Polyadenylation: alternative lifestyles of the A-rich (and famous?)

Alexa M Dickson  1 , Jeffrey Wilusz
Affiliations
Comment

Polyadenylation: alternative lifestyles of the A-rich (and famous?)

Alexa M Dickson et al. EMBO J. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Alternative 3′ end formation can require a choice between different types of polyadenylation signals. In a canonical poly(A) signal, the AAUAAA hexamer (bold) that interacts with CPSF is the dominant aspect, whereas in an A-rich poly(A) signal, the downstream U/GU element (bold) that interacts with CstF seems to be critical. The factors that are required to mediate usage of A-rich poly(A) signals are not clear, nor are the mechanisms that underlie alternative polyadenylation.
See this image and copyright information in PMC

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References

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