[Solid-state NMR spectroscopy and its pharmaceutical use]

Abstract

Liquid-state NMR spectroscopy has become an essential analytical tool in almost all fields of chemical research. However, the scope of NMR spectroscopy is not confined to the analysis of fluids. The progress in the investigation of solid samples is remarkably fast and solid-state NMR has developed to a high performance method. The majority of drug substances and products manufactured in the pharmaceutical industry are formulated in solid state, their analysis gains the increasing potential of solid-state NMR spectroscopy. The aim of this work is to survey the basics of solid-state NMR and to highlight some pharmaceutical applications focusing on polymorphism.