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. 2008 Sep;1(2):151-4.
doi: 10.1111/j.1752-8062.2008.00020.x.

The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers

David C Ishizawar  1 , Karen M Janosko, Jeffrey J Teuteberg, Linda M Cadaret, Michael A Mathier, Dennis M McNamara
Affiliations

The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers

David C Ishizawar et al. Clin Transl Sci. 2008 Sep.

Abstract

The role of beta-receptor selectivity for the interaction between the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and beta-blocker therapy was investigated in 479 subjects with left ventricular dysfunction. Subjects were separated into no beta-blocker, beta1 -selective, and nonselective beta-blocker treatment groups. The D allele adversely affected transplant-free survival for subjects not on beta-blockers (p= 0.004). Treatment with selective beta1-blockers eliminated the impact of the D allele (p= 0.51) in a manner similar to nonselective beta1,2-blockers (p= 0.80). Treatment with beta1-blockers was sufficient to eliminate the adverse impact of the ACE D allele, suggesting this pharmacogenetic interaction is mediated through the beta1-receptor.

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Figures

Figure 1
Figure 1
(A) Event‐free survival by ACE genotype with no β‐blocker therapy, n= 277, p= 0.004. (B) Event‐free survival by ACE genotype with β‐blocker therapy, n= 202, p= 0.97.
Figure 2
Figure 2
(A) Event‐free survival by ACE genotype, β1‐selective β‐blocker only (n= 85), p= 0.51. (B) Event‐free survival by ACE genotype, β1,2 nonselective β‐blocker (n= 117), p= 0.80.
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