Comment
doi: 10.1016/j.cmet.2010.04.010.
Lysosomal Rag-ulation of mTOR complex 1 activity
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- PMID: 20444413
- DOI: 10.1016/j.cmet.2010.04.010
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Comment
Lysosomal Rag-ulation of mTOR complex 1 activity
Cell Metab.
.
Free article
Abstract
An amino acid-sensing pathway regulates mTOR complex 1 (mTORC1) activity and participates in nutrient control of cell metabolism and growth. Sancak et al. (2010) identify a lysosomal membrane-localized super-complex that drives amino acid-dependent mTORC1 activation.
Comment on
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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8. Cell. 2010. PMID: 20381137 Free PMC article.
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