Comment
doi: 10.1016/j.cmet.2010.04.011.
Speaking from the heart: systemic copper signaling
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- PMID: 20444414
- DOI: 10.1016/j.cmet.2010.04.011
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Speaking from the heart: systemic copper signaling
Cell Metab.
.
Free article
Abstract
Copper is a ubiquitously essential nutrient for cells. In this issue of Cell Metabolism, Kim et al. (2010) demonstrate that tissue copper status can be communicated across organ systems. In a mouse model for cardiac copper deficiency, a serum-carried signal mobilized liver and intestinal copper by inducing ATP7A, a copper-exporting ATPase.
Comment on
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Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.Cell Metab. 2010 May 5;11(5):353-63. doi: 10.1016/j.cmet.2010.04.003. Cell Metab. 2010. PMID: 20444417 Free PMC article.
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