Intestinal ecology in the metabolic syndrome
- PMID: 20444415
- DOI: 10.1016/j.cmet.2010.04.012
Intestinal ecology in the metabolic syndrome
Abstract
Nutritional and genetic factors alter the intestinal microflora, predisposing individuals toward metabolic syndrome. Gewirtz and coworkers (Vijay-Kumar et al., 2010), employing Toll-like receptor 5 null mice, present evidence for a direct relationship between malfunction of the innate immune system, changes in gut microbiota composition, and development of metabolic syndrome.
Comment on
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Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.Science. 2010 Apr 9;328(5975):228-31. doi: 10.1126/science.1179721. Epub 2010 Mar 4. Science. 2010. PMID: 20203013 Free PMC article.
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