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Randomized Controlled Trial
. 2011 Apr;25(4):271-7.
doi: 10.1038/jhh.2010.45. Epub 2010 May 6.

The combination of amlodipine and angiotensin receptor blocker or diuretics in high-risk hypertensive patients: rationale, design and baseline characteristics

W Wang  1 , L Ma, Y Zhang, Q Deng, M Liu, L Liu
Affiliations
Randomized Controlled Trial

The combination of amlodipine and angiotensin receptor blocker or diuretics in high-risk hypertensive patients: rationale, design and baseline characteristics

W Wang et al. J Hum Hypertens. 2011 Apr.

Abstract

The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardial infarction and cardiovascular death events in high-risk Chinese hypertensive patients. The study also evaluates the long-term effects of lipid-lowering treatment and lifestyle modification. From October 2007 to October 2008, 13,542 patients were enrolled into the study in 180 centres in China. Patients will be followed up for 4 years. There was no difference in baseline characteristics between the two blood pressure arms.

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Figures

Figure 1
Figure 1
Study design. Abbreviations: A, amlodipine; CKD, chronic kidney disease; DBP, diastolic blood pressure; D, diuretic (amiloride 2.5 mg and hydrochlorothiazide 25 mg per tablet); M, month; SBP, systolic blood pressure; T, telmisartan; W, week.
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