Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;35(3):333-51.
doi: 10.1080/87565641003696940.

Diffusion tensor imaging of the cingulum bundle in children after traumatic brain injury

Elisabeth A Wilde  1 , Marco A Ramos, Ragini Yallampalli, Erin D Bigler, Stephen R McCauley, Zili Chu, Trevor C Wu, Gerri Hanten, Randall S Scheibel, Xiaoqi Li, Ana C Vásquez, Jill V Hunter, Harvey S Levin
Affiliations

Diffusion tensor imaging of the cingulum bundle in children after traumatic brain injury

Elisabeth A Wilde et al. Dev Neuropsychol. 2010.

Abstract

Structural damage to the prefrontal-cingulate network has been implicated in cognitive and neurobehavioral deficits associated with traumatic brain injury (TBI). Forty-six children who had sustained moderate-to-severe TBI and 43 children with extracranial injury were imaged using diffusion tensor imaging (DTI). Decreased fractional anisotropy (FA) and increased apparent diffusion coefficient (ADC) values were found in the cingulum bundles bilaterally in the TBI group. Cingulum ADC was related to frontal lesion volume, injury severity, and injury mechanism. Finally, cingulum DTI parameters were related to cognitive control measures. DTI detects TBI-related injury to the cingulum, which may facilitate advances in assessment and treatment.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Left cingulum bundle in a child with orthopedic injury (OI) and traumatic brain injury (TBI). Diffusion tensor imaging (DTI) tractography overlaid on a sagittal T1-weighted image for a 13-year-old child with OI compared with an age- and gender-equivalent child with TBI. Despite the lack of focal or diffuse injury in the TBI child at this level, DTI tractography illustrates the marked difference in the density, length, and brightness of the “fiber” streamlines (indications of decreased fractional anisotropy [FA] and/or increased apparent diffusion coefficient [ADC]) in this participant
FIGURE 2
FIGURE 2
See this image and copyright information in PMC

References

    1. Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4(3):316–329. - PMC - PubMed
    1. Arfanakis K, Haughton VM, Carew JD, Rogers BP, Dempsey RJ, Meyerand ME. Diffusion tensor MR imaging in diffuse axonal injury. American Journal of Neuroradiology. 2002;23(5):794–802. - PMC - PubMed
    1. Ashwal S, Holshouser BA, Tong KA. Use of advanced neuroimaging techniques in the evaluation of pediatric traumatic brain injury. Developmental Neuroscience. 2006;28(4–5):309–326. - PubMed
    1. Azouvi P. Neuroimaging correlates of cognitive and functional outcome after traumatic brain injury. Current Opinion of Neurology. 2000;13(6):665–669. - PubMed
    1. Benson RR, Meda SA, Vasudevan S, Kou Z, Govindarajan KA, Hanks RA, et al. Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury. Journal of Neurotrauma. 2007;24(3):446–459. - PubMed

Publication types

MeSH terms

LinkOut - more resources