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. 1991:40 Suppl 1:S65-7.

Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole

Y A Kesäniemi  1 , T A Miettinen
Affiliations
  • PMID: 2044647

Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole

Y A Kesäniemi et al. Eur J Clin Pharmacol. 1991.

Abstract

Neomycin and a benzodiazepine derivative (RO16-0521) inhibit similarly cholesterol absorption in man but the serum cholesterol level is reduced only by neomycin. Reason(s) for the difference are unknown. Ketoconazole inhibits 14 alpha-demethylation of lanosterol so that cholesterol synthesis is reduced. The agent inhibits also cholesterol absorption. The serum cholesterol level is reduced by about 20%, the lowering being potentiated by a simultaneous cholestyramine treatment.

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