Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991:40 Suppl 1:S65-7.

Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole

Y A Kesäniemi  1 , T A Miettinen
Affiliations
  • PMID: 2044647

Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole

Y A Kesäniemi et al. Eur J Clin Pharmacol. 1991.

Abstract

Neomycin and a benzodiazepine derivative (RO16-0521) inhibit similarly cholesterol absorption in man but the serum cholesterol level is reduced only by neomycin. Reason(s) for the difference are unknown. Ketoconazole inhibits 14 alpha-demethylation of lanosterol so that cholesterol synthesis is reduced. The agent inhibits also cholesterol absorption. The serum cholesterol level is reduced by about 20%, the lowering being potentiated by a simultaneous cholestyramine treatment.

PubMed Disclaimer

References

    1. Metabolism. 1991 Jan;40(1):35-41 - PubMed
    1. Eur J Clin Invest. 1987 Oct;17(5):391-5 - PubMed
    1. Scand J Clin Lab Invest. 1982 Apr;42(2):189-96 - PubMed
    1. Antimicrob Agents Chemother. 1980 Jun;17(6):922-8 - PubMed
    1. Lancet. 1984 Dec 1;2(8414):1271 - PubMed

MeSH terms

LinkOut - more resources