Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jun;22(3):402-10.
doi: 10.1016/j.coi.2010.04.002. Epub 2010 May 4.

Designing CD8+ T cell vaccines: it's not rocket science (yet)

Jonathan W Yewdell  1
Affiliations
Review

Designing CD8+ T cell vaccines: it's not rocket science (yet)

Jonathan W Yewdell. Curr Opin Immunol. 2010 Jun.

Abstract

CD8+ T cells play important roles in clearing viral infections and eradicating tumors. Designing vaccines that elicit effective CD8+ T cell responses requires a thorough knowledge of the pathways of antigen presentation in vivo. Here, I review recent progress in understanding the activation of naïve CD8+ T cells in vivo, with particular emphasis on cross-priming, the presentation of protein antigens acquired by dendritic cells from their environment. With the rapid advances in this area of research, the dawn of rational vaccine design is at hand.

PubMed Disclaimer

References

    1. Teng MW, et al. Immune-mediated dormancy: an equilibrium with cancer. J Leukoc Biol. 2008;84:988–993. - PubMed
    1. Crowe SR, et al. Vaccination with an acidic polymerase epitope of influenza virus elicits a potent antiviral T cell response but delayed clearance of an influenza virus challenge. J Immunol. 2005;174:696–701. - PubMed
    1. Yang OO, et al. Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL. J Immunol. 2003;171:3718–3724. - PubMed
    1. Kastenmuller W, et al. Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. The Journal of experimental medicine. 2007;204:2187–2198. - PMC - PubMed
    1. Oseroff C, et al. HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation. Proc Natl Acad Sci U S A. 2005;102:13980–13985. - PMC - PubMed