Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;137(3):435-9.
doi: 10.1007/s00432-010-0896-6. Epub 2010 May 7.

Influence of TGFB1+869T>C functional polymorphism in non-small cell lung cancer (NSCLC) risk

Ana L Teixeira  1 , António Araújo, Ana Coelho, Ricardo Ribeiro, Mónica Gomes, Carina Pereira, Rui Medeiros
Affiliations

Influence of TGFB1+869T>C functional polymorphism in non-small cell lung cancer (NSCLC) risk

Ana L Teixeira et al. J Cancer Res Clin Oncol. 2011 Mar.

Abstract

Purpose: Lung cancer is the third most common type of cancer in Europe and is the first cause of death by cancer worldwide. Non-small cell lung cancer accounts for 75-85% of all histological types of LC. The transforming growth factor beta 1 is a multifunctional regulatory polypeptide that controls many aspects of cellular function (cellular proliferation, differentiation, migration, apoptosis, immune surveillance). TGFB1+869T>C is a functional polymorphism described in TGFB1 gene and this transition has been associated with higher circulating levels of TGFß1 that may modulate cellular microenvironment and consequently LC development and prognosis.

Methods: We studied TGFB + 869T > C functional polymorphism by allelic discrimination using 7300 real-time polymerase chain reaction system in 305 patients with NSCLC and 380 healthy individuals.

Results: We found an increased risk for C carriers to develop NSCLC, both epidermoid NSCLC and non-epidermoid NSCLC (odds ratio (OR) = 2.03, P < 0.0001, OR = 2.37, P < 0.001 and OR = 1.83, P = 0.001, respectively). TGFB1+869T>C functional polymorphism may influence NSCLC susceptibility with impact in cellular microenvironment.

Conclusions: Our results suggest that individual differences influence the susceptibility to LC and tumoral behavior. This genetic profiling may help define higher risk groups for an individualized chemoprevention strategy and therapy.

PubMed Disclaimer

References

    1. Berndt SI, Huang WY, Chatterjee N, Yeager M, Welch R, Chanock SJ, Weissfeld JL, Schoen RE, Hayes RB (2007) Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma. Carcinogenesis 28:1965–1970 - PubMed
    1. Bierie B, Moses H (2006) TGF-b: the molecular Jekyll and Hyde of cancer. Nat Rev 6:506–520 - PubMed
    1. Blobe GC, Schiemann WP, Lodish HF (2000) Role of transforming growth factor ß in human disease. N England J Med 324:1350–1358 - PubMed
    1. Cohen V, Khuri FR (2004) Chemoprevention of lung cancer. Curr Opin Pulm Med 10:279–283 - PubMed
    1. Colakogullari M, Ulukaya E, Yilmaztepe A, Aymak F, Basturk B, Ursavas A, Oral HB (2008) The involvement of Il-10, IL-6, INF-γ, TNF-α, and TGF-ß gene polymorphisms among Turkish lung cancer patients. Cell Biochem Funct 26:283–290 - PubMed

Publication types

Substances