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. 1991 May;10(1):243-9.
doi: 10.1016/0888-7543(91)90506-a.

Linear order of new and established DNA markers around the fragile site at Xq27.3

M C Hirst  1 , A Roche, T J Flint, R N MacKinnon, J H Bassett, Y Nakahori, J E Watson, M V Bell, M N Patterson, Y Boyd, et al.
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Linear order of new and established DNA markers around the fragile site at Xq27.3

M C Hirst et al. Genomics. 1991 May.

Abstract

We have used recombinant clones derived from microdissection of the fragile X region to characterize breakpoints around the fragile site at Xq27.3. So far, no microdissection markers derived from Xq28 material have been found, thus allowing a rapid screening for clones surrounding the fragile site by their presence in a somatic cell hybrid containing Xq27.2-Xqter. A total of 43 new DNA markers from Xq27 have been sublocalized within this chromosome band. Of these new DNA markers, 5 lie in an interval defined as containing the fragile X region. The saturation of Xq27 with DNA markers by microdissection demonstrates the power of this technique and provides the resources for generating a complete physical map of the region.

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