Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2010 May;125(5):1125-7.
doi: 10.1016/j.jaci.2010.03.024.

Regulatory B cells that produce IL-10: a breath of fresh air in allergic airway disease

Thomas F Tedder, Takashi Matsushita
Editorial

Regulatory B cells that produce IL-10: a breath of fresh air in allergic airway disease

Thomas F Tedder et al. J Allergy Clin Immunol. 2010 May.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
IL-10-producing regulatory B10 cells inhibit allergic airway disease. Spleen B10pro cells mature into antigen-specific CD1dhiCD5+ regulatory B10 cells that are competent to produce and secrete IL-10 in response to allergen (antigen) challenge. Amu and colleagues show that spleen B10pro/B10 cells are induced to mature/expand in response to S. mansoni worm infection. The subsequent adoptive transfer of CD1dhi B cells purified from infected mice into allergen-sensitized recipients suppressed the induction of acute and allergic airway inflammation, which is proposed to result from the recruitment of Treg cells into the lungs of challenged mice. From our studies, B10 cells are also known to inhibit CD4+ T cell production of IFN-γ and TNF-α, to reduce the antigen-presenting capacity of DCs, and to reduce inflammatory responses through the production of IL-10. Thereby, B10 cells are likely to inhibit lung inflammation through multiple IL-10-dependent mechanisms of negative regulation.
See this image and copyright information in PMC

Comment on

References

    1. Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG. B regulatory cells prevent and reverse allergic airway inflammation via FoxP3+ Treg cells in a murine model. J Allergy Clin Immunol. 2010 in press. - PubMed
    1. Mangan NE, Fallon RE, Smith P, van Rooijen N, McKenzie AN, Fallon PG. Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. J Immunol. 2004;173:6346–56. - PubMed
    1. Yanaba K, Bouaziz J-D, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28:639–50. - PubMed
    1. Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM. B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3:944–50. - PubMed
    1. Matsushita T, Yanaba K, Bouaziz J-D, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest. 2008;118:3420–30. - PMC - PubMed