doi: 10.1016/0888-7543(91)90515-g.
Structure of the murine c-sis proto-oncogene (Sis, PDGFB) encoding the B chain of platelet-derived growth factor
Affiliations
- PMID: 2045107
- DOI: 10.1016/0888-7543(91)90515-g
Item in Clipboard
Structure of the murine c-sis proto-oncogene (Sis, PDGFB) encoding the B chain of platelet-derived growth factor
Genomics.
1991 May.
Abstract
The murine proto-oncogene c-sis (Sis, PDGFB), encoding the B chain of platelet-derived growth factor, has been cloned. Its structure, with seven exons spanning approximately 20 kb, closely resembles that of the human and feline homologs. The predicted amino acid sequence of murine PDGF-B has residues 89% identical to those of human PDGF-B. A noncoding region at the start of exon 7, which is deleted by alternative splicing during the generation of the viral v-sis oncogene, is highly conserved in human, mouse, and cat and may represent an important regulatory element.
Similar articles
-
Genetic organization of the c-sis transcription unit.Nucleic Acids Res. 1987 Feb 11;15(3):959-70. doi: 10.1093/nar/15.3.959. Nucleic Acids Res. 1987. PMID: 3822831 Free PMC article.
-
A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein.Nucleic Acids Res. 1995 Aug 11;23(15):2815-22. doi: 10.1093/nar/23.15.2815. Nucleic Acids Res. 1995. PMID: 7659502 Free PMC article.
-
Structure and nucleotide sequence of the 5' region of the human and feline c-sis proto-oncogenes.Nucleic Acids Res. 1986 Jan 24;14(2):765-78. doi: 10.1093/nar/14.2.765. Nucleic Acids Res. 1986. PMID: 3003695 Free PMC article.
-
[Expression and regulation of sis/GDGF-B chain in smooth muscle cell].Sheng Li Ke Xue Jin Zhan. 1994 Apr;25(2):165-8. Sheng Li Ke Xue Jin Zhan. 1994. PMID: 7973578 Review. Chinese. No abstract available.
-
Viral myc genes and their cellular homologs.Gene Amplif Anal. 1986;4:109-42. Gene Amplif Anal. 1986. PMID: 2851528 Review. No abstract available.
Cited by
-
Mouse chromosome 15.Mamm Genome. 1992;3 Spec No:S220-32. doi: 10.1007/BF00648433. Mamm Genome. 1992. PMID: 1498435 Review. No abstract available.
-
Angiogenic growth factors in neural embryogenesis and neoplasia.Am J Pathol. 1995 Feb;146(2):293-309. Am J Pathol. 1995. PMID: 7531952 Free PMC article. Review.
-
Signals controlling the expression of PDGF.Mol Biol Rep. 1995-1996;22(1):1-24. doi: 10.1007/BF00996300. Mol Biol Rep. 1995. PMID: 8858568 Review.
-
Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.Proc Natl Acad Sci U S A. 1993 May 15;90(10):4591-5. doi: 10.1073/pnas.90.10.4591. Proc Natl Acad Sci U S A. 1993. PMID: 8506304 Free PMC article.
-
Intraglomerular expressions of IL-1 alpha and platelet-derived growth factor (PDGF-B) mRNA in experimental immune complex-mediated glomerulonephritis.Clin Exp Immunol. 1994 Jan;95(1):29-34. doi: 10.1111/j.1365-2249.1994.tb06010.x. Clin Exp Immunol. 1994. PMID: 8287605 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
