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Review
. 2010 Aug;22(4):193-8.
doi: 10.1016/j.smim.2010.03.006. Epub 2010 May 6.

gammadelta T cell subsets: a link between TCR and function?

Rebecca L O'Brien  1 , Willi K Born
Affiliations
Review

gammadelta T cell subsets: a link between TCR and function?

Rebecca L O'Brien et al. Semin Immunol. 2010 Aug.

Abstract

The gammadelta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gammadelta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gammadelta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gammadelta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus.

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