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Review
. 2010 Aug;22(4):222-7.
doi: 10.1016/j.smim.2010.04.003. Epub 2010 May 6.

Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment

Kavitha Narayan  1 , Joonsoo Kang
Affiliations
Review

Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment

Kavitha Narayan et al. Semin Immunol. 2010 Aug.

Abstract

The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.

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References

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