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Review
. 2010 Aug;20(4):428-32.
doi: 10.1016/j.gde.2010.04.006. Epub 2010 May 6.

Fly fishing for collective cell migration

Affiliations
Review

Fly fishing for collective cell migration

Hernán López-Schier. Curr Opin Genet Dev. 2010 Aug.

Abstract

The collective migration of cells is essential for organogenesis. It requires the establishment of spatial information within the cellular group and a mechanism that controls the onset of cell movement and migratory arrest. In this review I will use two examples of collective cell migration, from Drosophila and the zebrafish, to discuss how genetic analyses have helped to unravel some basic aspects of collective cell migration. Following, I will suggest some general experimental approaches to further advance our understanding of the mechanisms that control the migration of cellular collectives.

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