Review
doi: 10.1016/j.tim.2010.04.001.
Epub 2010 May 6.
NF-kappaB signaling modulation by EBV and KSHV
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- PMID: 20452220
- DOI: 10.1016/j.tim.2010.04.001
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Review
NF-kappaB signaling modulation by EBV and KSHV
Trends Microbiol.
2010 Jun.
Abstract
The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.
Copyright 2010. Published by Elsevier Ltd.
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