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Comment
. 2010 May 7;6(5):399-400.
doi: 10.1016/j.stem.2010.04.004.

Dysfunctional niches as a root of hematopoietic malignancy

Yusuke Shiozawa  1 , Russell S Taichman
Affiliations
Free article
Comment

Dysfunctional niches as a root of hematopoietic malignancy

Yusuke Shiozawa et al. Cell Stem Cell. .
Free article

Abstract

Whether the bone marrow microenvironment can contribute to development of blood borne cancers is controversial. In a recent issue of Nature, Raaijmakers et al. (2010) show that deletion of Dicer1 specifically in osteoprogenitors not only impaired their differentiation but also resulted in disrupted blood formation and secondary leukemia.

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  • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.
    Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Raaijmakers MH, et al. Nature. 2010 Apr 8;464(7290):852-7. doi: 10.1038/nature08851. Epub 2010 Mar 21. Nature. 2010. PMID: 20305640 Free PMC article.

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