Review
doi: 10.1016/j.ccl.2010.01.017.
Genetic testing in aortic aneurysm disease: PRO
Affiliations
- PMID: 20452526
- PMCID: PMC3615454
- DOI: 10.1016/j.ccl.2010.01.017
Item in Clipboard
Review
Genetic testing in aortic aneurysm disease: PRO
Cardiol Clin.
2010 May.
Abstract
Thoracic aortic aneurysms leading to type A dissections (TAAD) are the major diseases affecting the aorta. A genetic predisposition for TAAD can occur as part of a genetic syndrome. It can be inherited in an autosomal dominant manner with decreased penetrance and variable expression. Genetic heterogeneity for familial TAAD has been demonstrated with the identification of four genes leading to TAAD. Genetic testing for TAAD and the phenotype and management of patients harboring mutations in these genes are addressed in this article.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment in
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Genetic testing in aortic aneurysm disease: CON.Cardiol Clin. 2010 May;28(2):199-204. doi: 10.1016/j.ccl.2010.02.002. Cardiol Clin. 2010. PMID: 20452527 Review.
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Editorial comment: genetic testing in aortic aneurysm disease.Cardiol Clin. 2010 May;28(2):205-6. doi: 10.1016/j.ccl.2010.02.007. Cardiol Clin. 2010. PMID: 20452528 No abstract available.
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