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Review
. 2010 Aug;14(4):456-66.
doi: 10.1016/j.cbpa.2010.04.008. Epub 2010 May 7.

The chemical biology of new drugs in the development for tuberculosis

Clifton E Barry 3rd  1 , John S Blanchard
Affiliations
Review

The chemical biology of new drugs in the development for tuberculosis

Clifton E Barry 3rd et al. Curr Opin Chem Biol. 2010 Aug.

Abstract

With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains.

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Figures

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Figure 1
Figure 2
Figure 2
Homology model of the Mtb c subunit of ATP synthase. Position 28 (left, spheres) is the aspartate residue equivalent to D32 in M. smegmatis. Position 63 (right sphere) is the Ala residue mutated to a Pro in the Mtb strain reisitant to TMC207. This figure was generously provided by Josh Goldman and Mark Girvin, Department of Biochemistry, Albert Einstein College of Medicine.
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Figure 6
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