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Comment
. 2010 Jun;12(6):522-4.
doi: 10.1038/ncb2066. Epub 2010 May 9.

alpha-catenin mechanosensing for adherens junctions

Thomas Lecuit  1
Affiliations
Comment

alpha-catenin mechanosensing for adherens junctions

Thomas Lecuit. Nat Cell Biol. 2010 Jun.

Abstract

The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation.

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