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. 2010 Jun;7(6):447-9.
doi: 10.1038/nmeth.1455. Epub 2010 May 9.

Coding of facial expressions of pain in the laboratory mouse

Dale J Langford  1 , Andrea L Bailey, Mona Lisa Chanda, Sarah E Clarke, Tanya E Drummond, Stephanie Echols, Sarah Glick, Joelle Ingrao, Tammy Klassen-Ross, Michael L Lacroix-Fralish, Lynn Matsumiya, Robert E Sorge, Susana G Sotocinal, John M Tabaka, David Wong, Arn M J M van den Maagdenberg, Michel D Ferrari, Kenneth D Craig, Jeffrey S Mogil
Affiliations

Coding of facial expressions of pain in the laboratory mouse

Dale J Langford et al. Nat Methods. 2010 Jun.

Abstract

Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.

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Comment in

  • Do mice have a pain face?
    Flecknell PA. Flecknell PA. Nat Methods. 2010 Jun;7(6):437-8. doi: 10.1038/nmeth0610-437. Nat Methods. 2010. PMID: 20508638 No abstract available.
  • The author file: Jeffrey Mogil.
    Banker M. Banker M. Nat Methods. 2010 Jun;7(6):415. doi: 10.1038/nmeth0610-415. Nat Methods. 2010. PMID: 20521366

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