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. 2010 Apr;65(4):383-7.
doi: 10.1590/S1807-59322010000400006.

Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease

Ruben Miguel Ayzin Rosoky  1 , Nelson Wolosker, Michel Nasser, Antonio Eduardo Zerati, Magnus Gidlund, Pedro Puech-Leão
Affiliations

Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease

Ruben Miguel Ayzin Rosoky et al. Clinics (Sao Paulo). 2010 Apr.

Abstract

Objectives: To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease.

Method: Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test.

Results: There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations.

Conclusions: Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.

Keywords: Atherosclerosis; Cholesterol; Free radical; Limb ischemia; Predictor.

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