Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease
- PMID: 20454495
- PMCID: PMC2862667
- DOI: 10.1590/S1807-59322010000400006
Oxidized low-density lipoprotein and ankle-brachial pressure index in patients with clinically evident peripheral arterial disease
Abstract
Objectives: To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding peripheral arterial disease.
Method: Eighty-five consecutive patients with an ankle-brachial pressure index (ABPI) < 0.9 and the presence of either intermittent claudication or critical lower leg ischemia were included. The plasma level of IgG autoantibodies against oxidized low-density lipoprotein was evaluated through an enzyme-linked immunosorbent assay. The results were categorized into quartiles according to the ankle-brachial pressure index (a marker of peripheral arterial disease severity), and significant differences were investigated with the Kruskal-Wallis test.
Results: There was no significant difference between the quartiles for this population (p = 0.33). No correlation was found between the ankle-brachial pressure index and oxidized low-density lipoprotein levels in subjects with clinically evident peripheral arterial disease with a wide range of clinical manifestations.
Conclusions: Oxidized low-density lipoprotein is not a good predictor of peripheral arterial disease severity.
Keywords: Atherosclerosis; Cholesterol; Free radical; Limb ischemia; Predictor.
References
-
- Nasser M, Wolosker N, Uint L, Rosoky RA, Lobato M, Wajngarten M, et al. Relationship between soluble thrombomodulin in patients with intermittent claudication and critical ischemia. Thromb Res. 2006;117:271–7. - PubMed
-
- Wolosker N, Rosoky RA, Nakano L, Basyches M, Puech-Leão P. Predictive value of the ankle-brachial index in the evaluation of intermittent claudication. Rev Hosp Clin Fac Med Sao Paulo. 2000;55:61–4. - PubMed
-
- Wild SH, Byrne CD, Smith FB, Lee AJ, Fowkes FG. Low ankle-brachial pressure index predicts increased risk of cardiovascular disease independent of the metabolic syndrome and conventional cardiovascular risk factors in the Edinburgh Artery Study. Diabetes Care. 2006;29:637–42. - PubMed
-
- Zaratin A, Gidlund M, Boschov P, Castilho L, de Faria EC. Antibodies against oxidized low-density lipoprotein in normolipidemic smokers. Am J Cardiol. 2002;90:651–3. - PubMed
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