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. 2011 Feb;15(1):197-201.
doi: 10.1007/s11030-010-9254-5. Epub 2010 May 8.

Synthesis of cyano-2,3-dihydropyrrolo[1,2-f]phenanthridine derivatives via a domino-Knoevenagel-cyclization

Ghasem Marandi  1 , Malek T Maghsoodlou, Nourallah Hazeri, Sayyed M Habibi-Khorassani, Niloufar Akbarzadeh Torbati, Faramarz Rostami-Charati, Brian W Skelton, Mohamed Makha
Affiliations

Synthesis of cyano-2,3-dihydropyrrolo[1,2-f]phenanthridine derivatives via a domino-Knoevenagel-cyclization

Ghasem Marandi et al. Mol Divers. 2011 Feb.

Abstract

In a new multicomponent reaction phenanthridine reacts with isocyanides and malonitrile in the presence of benzaldehyde derivatives to produce 2-aryl-3-(alkyl- or arylimino)-2,3-dihydropyrrolo[1,2-f]phenanthridine-1,1(12b H)-dicarbonitrile in a simple, mild, and efficient protocol in excellent yields.

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