[Diagnostic work-up and treatment of acute psycho-organic syndrome]
- PMID: 20454878
- PMCID: PMC7095979
- DOI: 10.1007/s00115-010-3013-9
[Diagnostic work-up and treatment of acute psycho-organic syndrome]
Abstract
Psychiatric disorders due to a medical or neurological condition are the main differential diagnoses in newly admitted psychiatric patients, consultations and outpatient settings. Especially with the growing elderly population delirium occurs more frequently, often due to multiple causes. Although its prognosis is known to be unfavourable, delirium too often remains undiagnosed or untreated. Medications, neurological diseases, infections as well as metabolic and other medical conditions have to be ruled out in the differential diagnosis using the patient's history, physical examination, laboratory results and imaging procedures. First-time psychiatric symptoms of an unknown medical disease as well as co-occurring psychiatric symptoms in chronic diseases provoke a challenging diagnostic decision, as reactive psychiatric symptoms have to be distinguished which is not always possible. In psychiatric disorders confirmed to be due to a medical condition, therapeutic implications are primarily geared to the causes of the disease. Only in a second step psychiatric medication is warranted with antipsychotic, antidepressant or sedation-inducing properties depending on the patient's symptoms.
Organische Ursachen akuter psychiatrischer Syndrome stellen die wichtigste Differenzialdiagnose bei psychiatrischen Akutaufnahmen, im Konsiliardienst und ambulanten Notdienst dar. Gerade mit der wachsenden Gruppe älterer Patienten treten Delirien, oft multifaktoriell ausgelöst, sehr häufig auf. Trotz ihrer ungünstigen Prognose bleiben sie allerdings zu oft unerkannt und unbehandelt. Medikamentöse, akutneurologische, infektiöse, metabolische und andere somatische Ursachen müssen differenzialdiagnostisch fundiert durch Anamnese, körperlichen Befund, Labor und Bildgebung ausgeschlossen werden. Erstmanifestationen wie auch psychiatrische Begleitsymptome stellen oft eine differenzialdiagnostische Herausforderung dar, auch in der teilweise allerdings nicht sicher möglichen Abgrenzung von reaktiven psychischen Störungen.
Bestätigt sich eine organische Ursache, ist die Therapie primär ursachenorientiert und erst in einem zweiten Schritt symptomatisch mit antipsychotischer, antidepressiver oder sedierender Medikation. Einer iatrogenen Verursachung von Delirien sowie deren Prävention gilt ein besonderes Augenmerk, um die medizinische Qualität gerade für Ältere zu verbessern.
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