Lymphoid cell lines: in vitro cell markers in correlation to tumorigenicity in nude mice
- PMID: 204550
- DOI: 10.1007/978-3-642-66639-1_36
Lymphoid cell lines: in vitro cell markers in correlation to tumorigenicity in nude mice
Abstract
Tumorigenicity of lymphoid cell lines of different origin upon xenotransplantation (s.c. and i.m.) in cell concentrations of 1 X 10(6) cell/inoculum into nude mice was correlated to karyotype, presence of the 14 q + marker, EBV reactivity and immunological markers. Lymphoblastoid cell lines (LCL), lacking the 14 q + marker failed to produce tumors independent upon diploidy or aneuploidy. Lymphoma-type lines of Burkitt lymphoma, lymphosarcoma and Hodgkins disease-origin, genotypically aneuploid, and expressing the 14 q + marker were tumorogenic in nude mice, when inoculated in the same cell quantities where LCL failed to form tumors. Tumorgrowth in nude mice was independent upon the presence of EBV in the inoculated cells.
Similar articles
-
Growth of diploid, Epstein-Barr virus-carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions.Int J Cancer. 1979 Jul 15;24(1):103-13. doi: 10.1002/ijc.2910240118. Int J Cancer. 1979. PMID: 225282
-
Intracranial heterotransplantation of human hematopoietic cells in nude mice.Int J Cancer. 1979 Jun 15;23(6):751-61. doi: 10.1002/ijc.2910230604. Int J Cancer. 1979. PMID: 38211
-
Lymphoid cell line identification and the detection of cross contamination.In Vitro. 1980 May;16(5):446-52. doi: 10.1007/BF02618368. In Vitro. 1980. PMID: 6248453
-
Immunological reactions to tumor-associated antigens in Burkitts lymphoma and other lymphomas.Cancer Res. 1974 May;34(5):1222-7. Cancer Res. 1974. PMID: 4366992 Review. No abstract available.
-
Biology and virology of the human malignant lymphomas: 1st Milford D. Schulz Lecture.Cancer. 1979 Jan;43(1):1-24. doi: 10.1002/1097-0142(197901)43:1<1::aid-cncr2820430102>3.0.co;2-m. Cancer. 1979. PMID: 83902 Review.
Cited by
-
Correlation of chromosomal aberrations in a myeloma cell line with tumorigenicity in nude mice.Blut. 1981 Aug;43(2):93-7. doi: 10.1007/BF00320467. Blut. 1981. PMID: 7260411
-
Hodgkin's disease: establishment and characterization of four in vitro cell lies.J Cancer Res Clin Oncol. 1981;101(1):111-24. doi: 10.1007/BF00405072. J Cancer Res Clin Oncol. 1981. PMID: 7276066 Free PMC article.