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Review
. 2010 Jun 15;50(12):e73-6.
doi: 10.1086/653011.

Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review

Yolanda Meije  1 , Manuel Lizasoain, Ana García-Reyne, Pilar Martínez, Virginia Rodríguez, Francisco López-Medrano, Rafael San Juan, Antonio Lalueza, José María Aguado
Affiliations
Review

Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review

Yolanda Meije et al. Clin Infect Dis. .

Abstract

Temozolomide chemotherapy has become part of the therapy used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Temozolomide frequently produces profound lymphopenia. We report 2 cases of cytomegalovirus disease that occurred in patients receiving temozolomide therapy and review 4 additional cases reported in the literature. Narrow monitoring with cytomegalovirus antigenemia assay should be considered for recommendation.

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