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Review
. 2010 Jun;63(6):601-10.
doi: 10.1111/j.1600-0897.2010.00852.x. Epub 2010 Apr 23.

Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy

Shigeru Saito  1 , Akitoshi Nakashima, Tomoko Shima, Mika Ito
Affiliations
Review

Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy

Shigeru Saito et al. Am J Reprod Immunol. 2010 Jun.

Abstract

T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

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