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Randomized Controlled Trial
. 2010 Jun;7(3):202-4.
doi: 10.1111/j.1742-481X.2010.00234.x. Epub 2010 Apr 23.

Assessment of the antimicrobial properties of maggots

Leon Margolin  1 , Philip Gialanella
Affiliations
Randomized Controlled Trial

Assessment of the antimicrobial properties of maggots

Leon Margolin et al. Int Wound J. 2010 Jun.

Abstract

Chronic bacterial colonisation or infection of wound is one of the major factors interfering proper wound healing, especially in diabetic foot ulcers. This study assesses the potential antimicrobial properties of maggots in vitro. This is a prospective randomised experimental study. Complete lysis of methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus and Candida albicans cultures in the area of maggot application was observed 24 hours after application of live maggots in all culture plates and was confirmed by Gram staining. This lysis persisted for more than 5 days after the maggot application. Complete lysis of the bacterial or fungal cultures in the area of maggot application provides convincing evidence for the antimicrobial property of maggots. This effect has a significant implication in management of diabetic foot ulcers and vascular ulcers.

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References

    1. Sherman RA, Hall MJ, Thomas S. Medicinal maggots: an ancient remedy for some contemporary afflictions. Annu Rev Entomol 2000;45:55–81. - PubMed
    1. Rayner K. Larval therapy in wound debridement. Prof Nurse 1999;14:329–33. - PubMed
    1. Sherman RA. Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair Regen 2002;10:208–14. - PubMed
    1. Sherman RA, Sherman J, Gilead L, Lipo M, Mumcuoglu KY. Maggot debridement therapy in outpatients. Arch Phys Med Rehabil 2001;82:1226–9. - PubMed
    1. Sherman RA, Wyle F, Vulpe M. Maggot therapy for treating pressure ulcers in spinal cord injury patients. J Spinal Cord Med 1995;18:71–4. - PubMed

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