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Review
. 2010 Jul;31(3):341-58.
doi: 10.1016/j.yfrne.2010.05.001. Epub 2010 May 10.

Of mice and rats: key species variations in the sexual differentiation of brain and behavior

P J Bonthuis  1 , K H Cox, B T Searcy, P Kumar, S Tobet, E F Rissman
Affiliations
Review

Of mice and rats: key species variations in the sexual differentiation of brain and behavior

P J Bonthuis et al. Front Neuroendocrinol. 2010 Jul.

Abstract

Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative animal models. As mice are gaining in popularity, it is essential to acknowledge the differences between these two rodents. Here we review neural and behavioral sexual dimorphisms in rats and mice, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons. Moving forward, investigators must answer fundamental questions about their chosen organism, and attend to both species and strain differences as they select the optimal animal models for their research questions.

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References

    1. Afonso VM, Lehmann H, Tse M, Woehrling A, Pfaus JG. Estrogen and the neural mediation of female-male mounting in the rat. Behav Neurosci. 2009:369–381. - PubMed
    1. Airaksinen MS, Thoenen H, Meyer M. Vulnerability of midbrain dopaminergic neurons in calbindin-D28k-deficient mice: lack of evidence for a neuroprotective role of endogenous calbindin in MPTP-treated and weaver mice. Eur J Neurosci. 1997:120–127. - PubMed
    1. Amateau SK, McCarthy MM. Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior. Nat Neurosci. 2004:643–650. - PubMed
    1. Anderson PJ, Fatinikun AE, Swift AD. Concentrations of testosterone in neonatal male rats suckled naturally and hand-fed. J Endocrinol. 1982:419–424. - PubMed
    1. Bakker J, Baum MJ. Role for estradiol in female-typical brain and behavioral sexual differentiation. Front Neuroendocrinol. 2008:1–16. - PMC - PubMed

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