doi: 10.1038/nbt0510-436.
Next-generation biomarkers for detecting kidney toxicity
Affiliations
- PMID: 20458311
- PMCID: PMC3033582
- DOI: 10.1038/nbt0510-436
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Next-generation biomarkers for detecting kidney toxicity
Nat Biotechnol.
2010 May.
Abstract
There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.
Figures
The utility of biomarkers to detect injury to specific nephron segments affected by various nephrotoxicants. (a) Nephron segment-specific biomarkers of kidney injury. (b) Drugs that elicit site-specific toxicity in the kidney,.
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