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. 2010 May;28(5):436-40.
doi: 10.1038/nbt0510-436.

Next-generation biomarkers for detecting kidney toxicity

Joseph V Bonventre  1 , Vishal S Vaidya, Robert Schmouder, Peter Feig, Frank Dieterle
Affiliations

Next-generation biomarkers for detecting kidney toxicity

Joseph V Bonventre et al. Nat Biotechnol. 2010 May.

Abstract

There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

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Figures

Figure 1
Figure 1
The utility of biomarkers to detect injury to specific nephron segments affected by various nephrotoxicants. (a) Nephron segment-specific biomarkers of kidney injury. (b) Drugs that elicit site-specific toxicity in the kidney,.
See this image and copyright information in PMC

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