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. 2010;12(2):304.
doi: 10.1186/bcr2561. Epub 2010 Apr 28.

On the theory of tumor self-seeding: implications for metastasis progression in humans

Julio A Aguirre-Ghiso  1
Affiliations

On the theory of tumor self-seeding: implications for metastasis progression in humans

Julio A Aguirre-Ghiso. Breast Cancer Res. 2010.

Abstract

Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.

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