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. 2010 Sep;95(9):1608-11.
doi: 10.3324/haematol.2010.022459. Epub 2010 May 11.

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia

Jasmine Healy  1 , Chantal Richer, Mathieu Bourgey, Ekaterini A Kritikou, Daniel Sinnett
Affiliations

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia

Jasmine Healy et al. Haematologica. 2010 Sep.

Abstract

Although childhood acute lymphoblastic leukemia is the most common pediatric cancer, its etiology remains poorly understood. In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia. We also confirmed a selective effect for B-cell acute lymphoblastic leukemia with hyperdiploidy and report a putative gender-specific effect of ARID5B SNPs on acute lymphoblastic leukemia risk in males. This study provides a strong rationale for more detailed analysis to identify the causal variants at this locus and to better understand the overall functional contribution of ARID5B to childhood acute lymphoblastic leukemia susceptibility.

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