Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2010 May 12:8:37.
doi: 10.1186/1477-7819-8-37.

Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma

Gianna Pace  1 , Pietro Saldutto, Carlo Vicentini, Lucio Miano
Affiliations
Randomized Controlled Trial

Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma

Gianna Pace et al. World J Surg Oncol. .

Abstract

Background: 30 patients, with T1 renal cell carcinomas (RCC) who underwent open enucleoresection of the tumour, were randomized to the use of a topical haemostatic agent (Floseal) or to an infrared-sapphire coagulator (ISC), to compare their efficacy in achieving haemostasis.

Methods: Successful intra-operative haemostasis, intra- and post-operative bleeding, operative time, hospital discharge were evaluated.

Results: Statistically higher rates of successful haemostasis and shorter time-to-haemostasis (8,1 vs 12,9 min) were observed in the FloSeal group (p < 0.001 both). Patients operative time was not different between Group 1 vs 2 (58.7 +/- 12 vs 62.4 +/- 15; p > 0.05). The average blood loss during surgery was less (60 +/- 25.5 mL) for the FloSeal group than for the ISC group (85 +/- 40.5 mL) (p < 0.05). Postoperative blood loss was 25 +/- 5 mL and 40 +/- 45 mL for Floseal and ISC respectively, (p < 0.05). Length of the postoperative hospital discharge was 2.5 +/- 1.2 days for FloSeal group and 3.5 +/- 1.3 for the Group 2 (p < 0.05). No major immediate or delayed complications were observed in either Groups.

Conclusions: The use of Floseal and ISC offer a safe and efficacy haemostasis in the enucleoresection of RCC. Moreover, our results show a less intra-operative and post-operative blood loss as well as a shorter time to haemostasis of Floseal in respect to ISC.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Nasso G, Piancone F, Bonifazi R, Romano V, Visicchio G, De Filippo CM, Impiombato B, Fiore F, Bartolomucci F, Alessandrini F, Speziale G. Prospective, Randomized Clinical Trial of the FloSeal Matrix Sealant in Cardiac Surgery. Ann Thorac Surg. 2009;88:1520–6. doi: 10.1016/j.athoracsur.2009.07.014. - DOI - PubMed
    1. Raga F, Sanz-Cortes M, Bonilla F, Casañ EM, Bonilla-Musoles. Reducing blood loss at myomectomy with use of a gelatin-thrombin matrix hemostatic sealant. Fertil Steril. 2009;92:356–60. doi: 10.1016/j.fertnstert.2008.04.038. - DOI - PubMed
    1. Testini M, Marzaioli R, Lissidini G, Lippolis A, Logoluso F, Gurrado A, Lardo D, Poli E, Piccinni G. The effectiveness of FloSeal matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study. Langenbecks Arch Surg. 2009;394:837–42. doi: 10.1007/s00423-009-0497-5. - DOI - PubMed
    1. Ebert AD, Hollauer A, Fuhr N, Langolf O, Papadopoulos T. Laparoscopic ovarian cystectomy without bipolar coagulation or sutures using a gelantine-thrombin matrix sealant (FloSeal): first support of a promising technique. Arch Gynecol Obstet. 2009;280:161–5. doi: 10.1007/s00404-009-0985-4. - DOI - PubMed
    1. Angioli R, Muzii L, Montera R, Damiani P, Bellati F, Plotti F, Zullo MA, Oronzi I, Terranova C, Panici PB. Feasibility of the use of novel matrix hemostatic sealant (FloSeal) to achieve hemostasis during laparoscopic excision of endometrioma. Minim Invasive Gynecol. 2009;16:153–6. doi: 10.1016/j.jmig.2008.11.007. - DOI - PubMed

Publication types