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Case Reports
. 2010 Apr;12(4):310-4.
doi: 10.1007/s12094-010-0510-z.

Response to erlotinib in recurrent glioblastoma multiforme showing coexpression of EGFRvIII and PTEN

A Custodio  1 , A Calles, P Pérez-Segura
Affiliations
Case Reports

Response to erlotinib in recurrent glioblastoma multiforme showing coexpression of EGFRvIII and PTEN

A Custodio et al. Clin Transl Oncol. 2010 Apr.

Abstract

Glioblastoma multiforme (GBM) is the most aggressive brain tumour in adults and remains incurable despite multimodal intensive treatment regimens. We present a patient with a recurrent glioblastoma who showed coexpression of the epidermal growth factor receptor mutant variant III (EGFRvIII) and the tumour-suppressor protein PTEN. She was treated with the tyrosine kinase inhibitor erlotinib for four months, achieving a partial response with improvement of neurologic symptoms. A review of the pertinent literature supporting the future use of therapies against epidermal growth factor receptor (EGFR) in highgrade gliomas is also provided.

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